The move will eliminate 9,500 jobs and U.S.-only domestic shipping by land and air, the company said.
The company said that new round of cuts are on top of another 5,400 job cuts it already announced and blamed heavy losses at the unit, which competes with UPS and FedEx.
John Allan, chief financial officer of Deutsche, said at a news conference that the job cuts and location closures would be across the country. There were no specific mentions of sites.
The cuts are part of a wider plan to curtail operations in the United States, including domestic ground and delivery services, though its international shipping to and from the United States will continue. The Express unit currently employs about 18,000 workers.
Part of the plan calls for the halt to domestic shipping by Jan. 30, the company said after it closes all of its ground hubs.
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